I. Best At-Home Syphilis Testing

Best At-Home Syphilis Tests BadgeMany companies have started offering at-home tests for sexually transmitted diseases. We evaluated the most popular options, focusing on several important metrics, including FDA-approval, convenience, and whether professional healthcare support is available. With these factors in mind, we determined the best services for at-home syphilis testing. Read our full methodology below.

II. Reviews of the Top Syphilis Tests



Everlywell is a testing company that offers at-home STD tests, including a stand-alone syphilis test. The test kits include easy-to-follow instructions and everything you need to collect a sample. All Everlywell tests are delivered in discreet packaging to ensure your privacy.

Everlywell’s syphilis test detects the presence or absence of the syphilis antibody using a finger prick sample collection. After collecting your sample, you mail it to a certified lab using the provided prepaid shipping. Everlywell only works with labs that are Clinical Laboratory Improvement Amendments (CLIA) certified by the federal government. This means they’ve met high standards for clinical laboratory testing to ensure that results are accurate and reliable.

Your results will be available within three to five days of the lab processing your sample. Once you receive an email indicating that your results are ready, you can access them through a secure online platform.

Everlywell tests are reviewed and approved by an independent board-certified physician within your state. If you test positive for syphilis, a member of Everlywell’s physician network will contact you as a courtesy to discuss your results in more detail. Typically, syphilis can be treated with antibiotics, and the physician network may offer the initial treatment.

Cost: $49




LetsGetChecked offers four levels of at-home STD testing. Two of the available kits test for syphilis along with other types of infections. The Standard 5 Kit tests for syphilis, chlamydia, gonorrhea, trichomoniasis, and HIV. The Complete 10 kit tests for syphilis and nine other STDs, including chlamydia, gonorrhea, trichomoniasis, HIV, syphilis, Gardnerella, mycoplasma, ureaplasma, and the herpes simplex virus 1 and 2.

After you receive your test, it must be activated before you collect your sample. Collection methods include a finger prick and urine sample. You must fast before collection, and you shouldn’t collect or return samples on a Friday, Saturday, or Sunday. LetsGetChecked advises collecting a sample before 9 a.m. and returning it the same day using the prepaid shipping label provided in your test kit.

Samples are processed in CLIA-certified and CPA-accredited labs to ensure accuracy and reliability. Once your sample arrives in the laboratory, results will be available through your secure online account within 2-5 days. LetsGetChecked has nurses available 24/7 and will call you to explain your results and provide treatment options.

Cost: $149-$349



myLab Box

MyLAB Box provides at-home tests for COVID-19, STDs, wellness, nutrition, fertility, and more. MyLAB Box offers three pricing tiers for STD test kits, including the Safe Box for $189, which tests for four STDs; the Uber Box at the cost of $269, which tests for seven STDs; and the Total Box for $399, which tests for 10 STDs. The STD tests, including a syphilis test, can also be purchased individually for $79.

MyLAB Box’s syphilis test requires collecting a small blood sample using a finger prick. Turnaround from order to results for the company’s syphilis and other STD test kits is estimated at 5-11 days. This includes 1-3 days to receive the kit and 2-8 days to process and post the results online. MyLAB Box works only with CLIA- and CAP-certified laboratories in the United States, ensuring results are accurate and reliable.

MyLAB Box sends an email notification with a link to a secure portal as soon as your results become available. If you test positive for syphilis using the service, you can receive a complimentary phone consultation with a myLAB Box physician affiliate to be evaluated for treatment. If you prefer to talk to your own physician, you can print a PDF version of your results and bring it with you to your appointment.

Cost: $79


Private iDNA


Private iDNA is an STD testing service that enables at-home STD testing. Private iDNA offers several pricing tiers for STD test kits ranging from $108 to $298 per kit. You can also select individual tests for $78 to $88, including a syphilis test for $78. At-home tests arrive in a plain, unbranded package and come complete with user-friendly directions for taking samples.

Testing for syphilis is performed using a small blood drop sample obtained by a finger prick. The test results will show with 99.9% accuracy whether or not a syphilis infection has been detected. Private iDNA uses an ELISA assay to detect antibodies to Treponema pallidum infections, which causes syphilis. Since the assay targets antibodies, individuals with previously treated syphilis will remain positive on this test. Therefore, this test cannot be used to differentiate between active and past cured cases.

Test results are provided in a report via a private, secure online portal. You can download your results anytime. In the case of any positive result, you can take your report to your physician for treatment. If you receive a positive STD result for a disease, you are eligible for a one time retest of that disease and pay only the cost of shipping and handling for the retest.

Cost: $78
Visit Private iDNA: https://www.idna.com


STD Rapid Test Kits


STD Rapid Test Kits provides STD test kits that are 98-99% accurate in detecting sexually transmitted diseases, including syphilis, chlamydia, gonorrhea, herpes-2, hepatitis B and C, and HIV 1 and 2. When you place an order test, your chosen test is dispatched within 48 hours. Delivery time varies depending on the courier service. Delivery with USPS typically takes 5-10 business days, while delivery with UPS takes 2-3 business days. All STD Rapid Test Kits are shipped in discreet packaging.

STD Rapid Test Kits don’t require laboratory work. The Syphilis Rapid Screen Test is a screening test for the detection of antibodies of Treponema pallidum in the blood using a finger prick test. Each test kit includes user-friendly instructions on how to complete the test and read the results. The results can be read after 15 minutes but no more than 20 minutes after taking the test by watching for the appearance of one or two purple lines. If both the control and test lines appear, the test is positive. If only the control line appears, the results are negative. If no lines or only the test line appears, the results are invalid, and a new test should be performed. If you receive a positive result, you should follow-up with your healthcare provider to receive treatment.

Cost: $29
Visit STD Rapid Test Kits: https://www.stdrapidtestkits.com

III. How We Chose the Best At-Home Syphilis Test

We selected our list of the best at-home syphilis tests based on criteria that are most important to consumers. These include services offered, certifications and lab safety, and professional support.

Services Offered

Many people prefer at-home syphilis testing because it offers both convenience and privacy. Therefore, we prioritized services that offer easy, discreet testing. To assess convenience, we looked at turnaround times, including how long customers have to wait to receive their kits and how long it takes to get results once their samples have been sent to the lab. We also prioritized companies that include discrete packaging and prepaid envelopes for samples, to ensure testing is private and simple to complete.

Certifications and Lab Safety

The quality of at-home tests may vary, therefore, we only included companies that offer tests that have been expertly evaluated for safety and effectiveness. To that end, We looked at companies that use FDA-approved laboratory tests or CLIA-certified and CAP-accredited labs.

Professional Support

Learning you have a positive syphilis test can be frightening. Therefore, we prioritize tests that offer support from healthcare professionals to help you determine the appropriate next steps in the event of a positive test. A healthcare provider can help you understand what your results mean, whether further testing is needed, how to access treatment, and how to inform your partner(s).

IV. At-Home Syphilis FAQs

What is at-home syphilis testing?

At-home syphilis testing allows you to test for syphilis from the comfort and privacy of your own home. Most home-based syphilis tests require you to collect a blood sample using a simple finger prick and mail your sample to a certified lab with prepaid shipping. Companies offering at-home syphilis tests provide varying degrees of support after delivering your test results. This may include counseling or treatment delivered remotely by a healthcare professional.

Is at-home syphilis testing effective?

In order to provide accurate and reliable results, an at-home syphilis test must be performed correctly. Typically, at-home syphilis tests require a blood sample, which can be obtained by capillary sampling from a finger, also known as finger prick. It’s important to follow the instructions provided with your test kit to increase the likelihood of accurate results. Many tests are 98-99% accurate in the detection of syphilis.

What are the benefits of at-home Syphilis testing?

At-home syphilis tests offer many benefits. These include:

  • Accessibility: If it’s difficult to access a healthcare provider for syphilis testing, at-home tests can provide an alternative to in-person tests.
  • Convenience: At-home tests don’t require you to visit a clinic, meaning you can complete testing in as little as five minutes.
  • Privacy: If you don’t want anyone to know you’re getting tested for syphilis, at-home options can offer more privacy.
  • Less stigma: If you’re worried about talking about your sexual health with your healthcare provider, at-home testing can help you avoid any stigma.
  • Specific testing options: You can choose to complete a single test, such as a syphilis test or a full STD panel.

How much does at-home syphilis testing cost?

The cost of at-home syphilis testing varies based on factors such as the company offering the test and whether you have health insurance coverage for STD testing. Most at-home syphilis tests cost between $29 and $79, without insurance. Some services also accept FSA and HSA cards, which allow you to use pretax income to cover medical expenses.