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Formal Name:
Retinol

This article was last modified on November 9, 2021

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At a Glance

Why Get Tested?

To detect vitamin A deficiency or toxicity

When To Get Tested?

When you have symptoms suggesting a vitamin A deficiency or excess, or are at risk for a deficiency

Sample Required?

A blood sample drawn from a vein

Test Preparation Needed?

Fasting is required and no alcohol should be consumed for 24 hours before sample collection.

Looking For Test Results?

Looking For Reference Ranges?

You may be able to find your test results on your laboratory’s website or patient portal. However, you are currently at Testing.com. You may have been directed here by your lab’s website in order to provide you with background information about the test(s) you had performed. You will need to return to your lab’s website or portal, or contact your healthcare practitioner in order to obtain your test results.

Testing.com is an award-winning patient education website offering information on laboratory tests. The content on the site, which has been reviewed by laboratory scientists and other medical professionals, provides general explanations of what results might mean for each test listed on the site, such as what a high or low value might suggest to your healthcare practitioner about your health or medical condition.

The reference ranges for your tests can be found on your laboratory report. They are typically found to the right of your results.

If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.

Laboratory test results are not meaningful by themselves. Their meaning comes from comparison to reference ranges. Reference ranges are the values expected for a healthy person. They are sometimes called “normal” values. By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. Values that are outside expected ranges can provide clues to help identify possible conditions or diseases.

While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. This is a reason why so few reference ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are “within normal limits.”

For more information, please read the article Reference Ranges and What They Mean.

What is being tested?

Vitamin A is a fat-soluble vitamin that is naturally present in many of the foods we eat. Retinol is the primary form of vitamin A in humans. This test measures the level of retinol in the blood.

Vitamin A is an essential nutrient required for healthy vision and skin, bone formation, immune system function, and reproduction. It is required to produce photoreceptors in the eyes and to maintain the lining of the surface of the eyes and other mucous membranes. A lack of vitamin A can affect night vision, cause eye damage, and in severe cases, lead to blindness. Too much vitamin A can be toxic, causing a range of symptoms, and sometimes leading to birth defects.

The body cannot make vitamin A and must rely on dietary sources of vitamin A. Meat sources provide vitamin A (as retinol), while vegetable and fruit sources provide carotene (a substance that can be converted into vitamin A by the liver). Vitamin A is stored in the liver and fat tissues (it is fat-soluble), and healthy adults may have as much as a year’s worth stored. The body maintains a relatively stable level in the blood through a feedback system that releases vitamin A from storage as needed and increases or decreases the efficiency of dietary vitamin A absorption.

Deficiencies in vitamin A are rare in the United States, but they are a major health problem in as many as half of all countries, especially in resource-poor nations where high numbers of people have limited diets, according to the World Health Organization (WHO). One of the first signs of vitamin A deficiency is night blindness. Young children and pregnant women are most commonly affected, say the WHO.

In the U.S., vitamin A deficiencies are primarily seen in those with malnutrition, chronic diarrhea, malabsorption disorders such as celiac disease, cystic fibrosis, or chronic pancreatitis, in the elderly, and in those with alcoholism, liver disease and blockage of the bile ducts. Surgery either on the intestine or pancreas can have the similar consequences.

Vitamin A deficiency is a risk factor for severe measles; treatment with vitamin A can shorten the duration of the disorder and may reduce the severity of symptoms and risk of death.

Vitamin A toxicity occurs primarily from overuse of vitamin supplements. However, it can sometimes occur when the diet includes a high proportion of foods that are high in vitamin A, such as liver.

Common Questions

How is the test used?

Vitamin A testing is used to help diagnose a vitamin A deficiency in people with signs and symptoms, such as night blindness, or in people who are at risk of vitamin A deficiency. Testing for this purpose is not common because vitamin A deficiencies are rare in the United States.

Sometimes testing may be used to detect toxic levels caused by consuming large amounts of vitamin A.

When is it ordered?

A vitamin A test may be ordered when you have signs and symptoms that suggest a vitamin A deficiency or you have general malnutrition. These signs and symptoms include:

Night blindness
Dry eyes, skin, and hair
Ulcers and damage to the cornea, the outermost layer of the front of the eye that covers the iris and pupil
Skin thickening and lesions
Grayish spots on eye lining (Bitot spots)
Repeated infections
Anemia

Testing may be done periodically when you have a disease that is associated with malabsorption of nutrients, such as:

Celiac disease
Irritable bowel syndrome
Crohns disease, a type of inflammatory bowel disease

Testing may be performed when your signs and symptoms and medical history suggest vitamin A toxicity. If you have vitamin A toxicity, you may experience:

Headache
Nausea and vomiting
Double or blurred vision
Fatigue
Weakness
Dizziness
Seizures
Irritability
Muscle pain
Bone and joint pain
Weight loss
Hair loss
Mucous membrane dryness
Itching
Liver dysfunction
Cracks (fissures) at the corners of the mouth
Inflammation of the tongue (glossitis)

What does the test result mean?

A normal vitamin A blood level means you currently have enough vitamin A, but it does not indicate how much you have stored in reserve. The body will maintain vitamin A in the blood at a relatively stable level until stores are low.

A low vitamin A blood test result means you lack enough vitamin A (deficiency). This can lead to night blindness, among other complications.

A high vitamin A blood level typically means too much vitamin A is circulating in the blood and may be deposited in other parts of the body, leading to toxicity. Getting too much vitamin A, usually from supplements or certain medications, can cause dizziness, headaches, and nausea. In serious cases, it can lead to coma and be life-threatening. In pregnant women, too much vitamin A can cause birth defects in their babies.

Is there anything else I should know?

People with a minimal amount of vitamin A stored may have marginal but adequate vitamin A until they have an illness or other condition, such as pregnancy, that puts increased demands on their body. This is one of the reasons that night blindness is prevalent in many parts of the world during pregnancy.

Eating excessive amounts of foods with beta carotene, such as carrots, can cause a person’s skin to turn yellow-orange but it does not cause vitamin A toxicity. The body does not convert beta carotene to vitamin A when there is sufficient vitamin A present.

What are the dietary sources of vitamin A?

Sources of preformed vitamin A include meat (especially liver), eggs, dairy products, and fortified foods. Sources of carotene (mainly beta carotene) include brightly colored fruits and vegetables such as carrots, spinach, apricots, sweet potatoes, and cantaloupe.

What are the recommended dietary allowances (RDA) for vitamin A?

For teens and adults age 14 and older, the RDA is 900 micrograms (mcg) (3,000 IU) for males and 700 mcg (2,310 IU) for females. The recommendations for others, such as infants, children and pregnant women, vary. For these, see the lists provided by the National Institutes of Health Office of Dietary Supplements.

How are vitamin A deficiencies treated?

Mild to moderate deficiencies are treated with supplements and/or with alterations in diet. More severe deficiencies may require monitored therapeutic doses of vitamin A.

Can vitamin A testing be done in my healthcare practitioner's office?

No, this test requires specialized equipment and is not offered by every laboratory. In many cases, your blood will be sent to a reference laboratory.

View Sources

Sources Used in Current Review

2020 Review performed by Hoon Loi, Chong, MD, FASN, FRSPH, IPFPH, Physician, MJ Health Care Centre.

Johnson L. Vitamin A Deficiency. Nutrition Disorders. MSD Manual Professional Edition. Last full review August 2020.

(February 14, 2020) NIH, Office of Dietary Supplements (ODS). Vitamin A. Available online at https://ods.od.nih.gov/factsheets/VitaminA-Consumer/. Accessed May 2020.

(May 28, 2020) Olson J, Ameer M, Goyal A. Vitamin A Toxicity. StatPearls. Available online at https://www.ncbi.nlm.nih.gov/books/NBK532916/. Accessed May 2020.

(2020) World Health Organization. Micronutrient deficiencies. Vitamin A deficiency. Available online at https://www.who.int/nutrition/topics/vad/en/. Accessed May 2020.

Sources Used in Previous Reviews

Schwartz, R. et. al. (Updated 2011 January 7). Dermatologic Manifestations of Vitamin A Deficiency. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/1104441-overview. Accessed March 2011.

Ansstas, G. and Thakore, J. (Updated 2010 December 28). Vitamin A Deficiency. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/126004-overview. Accessed March 2011.

Eledrisi, M. et. al. (Updated 2009 September 2). Vitamin A Toxicity. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/126104-overview. Accessed March 2011.

Dugdale, D. (Updated 2009 November 15). Vitamin A test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003570.htm. Accessed March 2011.

Vorvick, L. (Updated 2009 November 1). Beta-carotene test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003571.htm. Accessed March 2011.

Dugdale, D. (Updated 2010 May 23). Hypervitaminosis A. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000350.htm. Accessed March 2011.

Frank, E. et. al. (Updated 2010 December). Vitamins. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Vitamins.html?client_ID=LTD. Accessed March 2011.

(© 1995-2011). Unit Code 60298: Vitamin A, Serum. Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/print.php?unit_code=60298. Accessed March 2011.

Barclay, L. (2010 December 8). Vitamin A May Reduce Deaths From Measles and Diarrhea in Children. Medscape Today from Medscape Medical News [On-line information]. Available online at http://www.medscape.com/viewarticle/733832. Accessed March 2011.

Wisse, B. (2014 May 10 Updated). Hypervitaminosis A. MedlinePlus Medical Encyclopedia [On-line information]. Available online at https://www.nlm.nih.gov/medlineplus/ency/article/000350.htm. Accessed on 8/29/15.

Dugdale, D. (2013 November 1 Updated). Vitamin A blood test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at https://www.nlm.nih.gov/medlineplus/ency/article/003570.htm. Accessed on 8/29/15.

Frank, E. et. al. (2015 July Updated). Vitamins. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Vitamins.html?client_ID=LTD#tabs=0. Accessed on 8/29/15.

Ansstas, G. et. al. (2014 June 11 Updated). Vitamin A Deficiency. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/126004-overview. Accessed on 8/29/15.

Rosenbloom, M. and Gentili, A. (2014 October 14 Updated). Vitamin Toxicity. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/819426-overview. Accessed on 8/29/15.

(© 1995–2015). Vitamin A, Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/60298. Accessed on 8/29/15.

(Sept 29, 2009) Lieber C. Relationships Between Nutrition, Alcohol Use, and Liver Disease. National Institute on Alcohol Abuse and Alcoholism. Available online at http://pubs.niaaa.nih.gov/publications/arh27-3/220-231.htm. Accessed October 2015.

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